Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats.

R-00018-2004-R2 Decreased Epoxygenase and Increased Epoxide Hydrolase Expression in the Mesenteric Artery of Obese Zucker Rats

CALL FOR PAPERS Regulation of Cardiovascular Functions by Eicosanoids and Other Lipid Mediators PPAR- activator fenofibrate increases renal CYP-derived eicosanoid synthesis and improves endothelial dilator function in obese Zucker rats

Zhao, Xueying, Jeffrey E. Quigley, Jianghe Yuan, Mong-Heng Wang, Yiqing Zhou, and John D. Imig. PPARactivator fenofibrate increases renal CYP-derived eicosanoid synthesis and improves endothelial dilator function in obese Zucker rats. Am J Physiol Heart Circ Physiol 290: H2187–H2195, 2006. First published February 24, 2006; doi:10.1152/ajpheart.00937.2005.—Previous studies have shown that the s...

Reduced Endothelium-Dependent Relaxation to Anandamide in Mesenteric Arteries from Young Obese Zucker Rats

Impaired vascular function, manifested by an altered ability of the endothelium to release endothelium-derived relaxing factors and endothelium-derived contracting factors, is consistently reported in obesity. Considering that the endothelium plays a major role in the relaxant response to the cannabinoid agonist anandamide, the present study tested the hypothesis that vascular relaxation to ana...

Progression of coronary and mesenteric vascular dysfunction in Zucker obese and Zucker diabetic fatty rats.

We investigated the progression of vascular dysfunction associated with the metabolic syndrome with and without hyperglycemia in lean, Zucker obese, and Zucker diabetic fatty (ZDF) rats. Responses of aorta and small coronary and mesenteric arteries were measured to endothelium-dependent and -independent vasodilators. Indices of oxidative stress were increased in serum from ZDF rats throughout t...

Hepatic Oxidative Stress, Genotoxicity and Vascular Dysfunction in Lean or Obese Zucker Rats

Metabolic syndrome is associated with increased risk of cardiovascular disease, which could be related to oxidative stress. Here, we investigated the associations between hepatic oxidative stress and vascular function in pressurized mesenteric arteries from lean and obese Zucker rats at 14, 24 and 37 weeks of age. Obese Zucker rats had more hepatic fat accumulation than their lean counterparts....